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Has an MLB game ever ended 21-6?

Yes. MLB has seen a final score of 21-6 8 times. It first happened on July 17, 1883, when Buffalo Bisons beat Philadelphia Quakers, and most recently on August 25, 2004, when Anaheim Angels beat Kansas City Royals.

Where 21-6 sits among nearby MLB scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 21-6 the 205th most common final score out of 330 that have ever occurred in MLB. One point away, 22-6 has happened 6 times and 21-7 has happened 13 times. At one point the score disappeared for 51 years, between 1936 and 1987.

Every 21-6 in MLB history

DateResultSeason
2004-08-25Anaheim Angels over Kansas City Royals2004
1987-09-15Cincinnati Reds over Atlanta Braves1987
1936-07-01Detroit Tigers over Chicago White Sox1936
1914-08-16Indianapolis Hoosiers over Pittsburgh Rebels1914
1902-08-25Baltimore Orioles over Chicago White Sox1902
1899-07-17Baltimore Orioles over Cleveland Spiders1899
1896-04-20Boston Beaneaters over Baltimore Orioles1896
1883-07-17Buffalo Bisons over Philadelphia Quakers1883
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Open the MLB grid at 21-6