Has an MLB game ever ended 22-13?

Exactly once. On May 31, 1970, Chicago White Sox beat Boston Red Sox 22-13, and no MLB game before or since has ended that way. When it happened it was a scorigami, the first 22-13 in league history.

Where 22-13 sits among nearby MLB scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 22-13 the 278th most common final score out of 330 that have ever occurred in MLB. One point away, 23-13 has happened 1 times and 22-14 has happened 3 times.

Every 22-13 in MLB history

Date	Result	Season
1970-05-31	Chicago White Sox over Boston Red Sox	1970

Open the MLB grid at 22-13