Has an MLB game ever ended 22-21?
Exactly once. On April 18, 1890, Brooklyn Gladiators beat Syracuse Stars 22-21, and no MLB game before or since has ended that way. When it happened it was a scorigami, the first 22-21 in league history.
That makes 22-21 the 278th most common final score out of 330 that have ever occurred in MLB. One point away, 23-21 has happened never and 22-22 has happened never.
Every 22-21 in MLB history
| Date | Result | Season | |
|---|---|---|---|
| 1890-04-18 | Brooklyn Gladiators over Syracuse Stars | 1890 |