Has an MLB game ever ended 22-3?
Yes. MLB has seen a final score of 22-3 5 times. It first happened on May 5, 1880, when Cleveland Blues beat Buffalo Bisons, and most recently on September 4, 1999, when Cincinnati Reds beat Philadelphia Phillies.
That makes 22-3 the 220th most common final score out of 330 that have ever occurred in MLB. One point away, 23-3 has happened 9 times and 22-4 has happened 8 times. At one point the score disappeared for 109 years, between 1890 and 1999.
Every 22-3 in MLB history
| Date | Result | Season | |
|---|---|---|---|
| 1999-09-04 | Cincinnati Reds over Philadelphia Phillies | 1999 | |
| 1890-06-24 | Chicago Pirates over Brooklyn Ward's Wonders | 1890 | |
| 1884-07-04 | Chicago White Stockings over Philadelphia Quakers | 1884 | |
| 1884-07-04 | Boston Reds over Kansas City Cowboys | 1884 | |
| 1880-05-05 | Cleveland Blues over Buffalo Bisons | 1880 |