Has an MLB game ever ended 28-16?

Exactly once. On July 12, 1890, Brooklyn Ward's Wonders beat Buffalo Bisons 28-16, and no MLB game before or since has ended that way. When it happened it was a scorigami, the first 28-16 in league history.

Where 28-16 sits among nearby MLB scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 28-16 the 278th most common final score out of 330 that have ever occurred in MLB. One point away, 29-16 has happened never and 28-17 has happened never.

Every 28-16 in MLB history

Date	Result	Season
1890-07-12	Brooklyn Ward's Wonders over Buffalo Bisons	1890

Open the MLB grid at 28-16