Has an NCAA Men's Basketball game ever ended 109-53?

Exactly once. On November 23, 2021, Southern Jaguars beat Ecclesia College Royals 109-53, and no NCAA Men's Basketball game before or since has ended that way. When it happened it was a scorigami, the first 109-53 in league history.

Where 109-53 sits among nearby NCAA Men's Basketball scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 109-53 the 3033rd most common final score out of 3,866 that have ever occurred in NCAA Men's Basketball. One point away, 110-53 has happened 8 times and 109-54 has happened 4 times.

Every 109-53 in NCAA Men's Basketball history

Date	Result	Season
2021-11-23	Southern Jaguars over Ecclesia College Royals	2022

Open the NCAA Men's Basketball grid at 109-53