Has an NCAA Men's Basketball game ever ended 52-45?
It has. 52-45 has been a NCAA Men's Basketball final 22 times in 136,843 games. The first was Marquette Golden Eagles beat St. John's Red Storm on November 13, 2003; the latest was Appalachian State Mountaineers beat UL Monroe Warhawks on February 9, 2023.
That makes 52-45 the 1196th most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 53-45 has happened 13 times and 52-46 has happened 14 times.