Has an NCAA Men's Basketball game ever ended 53-46?
It has. 53-46 has been a NCAA Men's Basketball final 19 times in 136,843 games. The first was San Francisco Dons beat Ohio Bobcats on December 13, 2003; the latest was San Diego State Aztecs beat Fresno State Bulldogs on March 10, 2022.
That makes 53-46 the 1266th most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 54-46 has happened 21 times and 53-47 has happened 12 times. Nearly all of its occurrences fall between 2010 and 2039.