Has an NCAA Men's Basketball game ever ended 78-25?

Exactly once. On December 29, 2015, Missouri Tigers beat Arkansas-Pine Bluff Golden Lions 78-25, and no NCAA Men's Basketball game before or since has ended that way. When it happened it was a scorigami, the first 78-25 in league history.

Where 78-25 sits among nearby NCAA Men's Basketball scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 78-25 the 3013th most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 79-25 has happened never and 78-26 has happened never.

Every 78-25 in NCAA Men's Basketball history

Date	Result	Season
2015-12-29	Missouri Tigers over Arkansas-Pine Bluff Golden Lions	2016

Open the NCAA Men's Basketball grid at 78-25