Has an NCAA Men's Basketball game ever ended 80-43?
Yes. NCAA Men's Basketball has seen a final score of 80-43 16 times. It first happened on December 3, 2004, when Western Illinois Leathernecks beat Harris Stowe Hornets, and most recently on November 21, 2025, when Santa Clara Broncos beat Louisiana Ragin' Cajuns.
That makes 80-43 the 1352nd most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 81-43 has happened 8 times and 80-44 has happened 10 times.