Has an NCAA Men's Basketball game ever ended 80-45?
Yes. NCAA Men's Basketball has seen a final score of 80-45 17 times. It first happened on December 20, 2002, when Western Kentucky Hilltoppers beat St. Francis (PA) Red Flash, and most recently on March 11, 2026, when Nevada Wolf Pack beat Air Force Falcons.
That makes 80-45 the 1323rd most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 81-45 has happened 18 times and 80-46 has happened 20 times. Nearly all of its occurrences fall between 2010 and 2039.