Has an NCAA Men's Basketball game ever ended 80-49?
Yes. NCAA Men's Basketball has seen a final score of 80-49 21 times. It first happened on December 6, 2002, when Missouri State Bears beat Samford Bulldogs, and most recently on November 14, 2025, when Saint Mary's Gaels beat North Texas Mean Green.
That makes 80-49 the 1224th most common final score out of 3,845 that have ever occurred in NCAA Men's Basketball. One point away, 81-49 has happened 33 times and 80-50 has happened 38 times. Nearly all of its occurrences fall between 2010 and 2039.