Has a College Football game ever ended 100-6?
Exactly once. On November 23, 1968, Houston beat Tulsa 100-6, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 100-6 in league history.
That makes 100-6 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 101-6 has happened never and 100-7 has happened never.