Has a College Football game ever ended 115-0?
Exactly once. On November 1, 1890, Princeton beat Virginia 115-0, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 115-0 in league history.
That makes 115-0 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 116-0 has happened never and 115-1 has happened never.