Has a College Football game ever ended 158-0?
Exactly once. On November 3, 1886, Harvard beat Exeter 158-0, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 158-0 in league history.
That makes 158-0 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 159-0 has happened never and 158-1 has happened never.