Has a College Football game ever ended 25-4?
Exactly once. On October 26, 1907, Iowa beat Drake 25-4, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 25-4 in league history.
That makes 25-4 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 26-4 has happened 7 times and 25-5 has happened 2 times.