Has a College Football game ever ended 43-19?
Yes. College Football has seen a final score of 43-19 5 times. It first happened on October 3, 1947, when Maryland beat Delaware, and most recently on September 1, 2012, when Virginia beat Richmond.
That makes 43-19 the 1293rd most common final score out of 2,216 that have ever occurred in College Football. One point away, 44-19 has happened 7 times and 43-20 has happened 12 times. At one point the score disappeared for 52 years, between 1947 and 1999.