Has a College Football game ever ended 43-2?
Exactly once. On November 19, 1960, Rutgers beat Columbia 43-2, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 43-2 in league history.
That makes 43-2 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 44-2 has happened 1 times and 43-3 has happened 10 times.