Has a College Football game ever ended 43-5?
It has. 43-5 has been a College Football final 2 times in 84,334 games. The first was Harvard beat MIT on October 18, 1884; the latest was Nebraska beat Doane on November 25, 1905.
That makes 43-5 the 1610th most common final score out of 2,215 that have ever occurred in College Football. One point away, 44-5 has happened 2 times and 43-6 has happened 12 times.