Has a College Football game ever ended 45-21?
It has. 45-21 has been a College Football final 100 times in 84,334 games. The first was Villanova beat NC State on November 19, 1949; the latest was Duke beat California on October 5, 2025.
That makes 45-21 the 216th most common final score out of 2,215 that have ever occurred in College Football. One point away, 46-21 has happened 12 times and 45-22 has happened 25 times.
Every 45-21 in College Football history
| Date | Result | Season | |
|---|---|---|---|
| 2025-10-05 | Duke over California | 2025 | |
| 2025-09-06 | Toledo over Western Kentucky | 2025 | |
| 2023-12-26 | Texas State over Rice | 2023 | Playoff |
| 2023-11-24 | Memphis over Temple | 2023 | |
| 2023-11-11 | SMU over North Texas | 2023 | |
| 2023-10-28 | Western Michigan over Eastern Michigan | 2023 | |
| 2023-10-21 | Memphis over UAB | 2023 | |
| 2022-10-22 | Duke over Miami | 2022 | |
| 2021-12-05 | Pittsburgh over Wake Forest | 2021 | |
| 2021-11-27 | Tennessee over Vanderbilt | 2021 | |
| 2020-12-12 | Louisville over Wake Forest | 2020 | |
| 2020-12-05 | Notre Dame over Syracuse | 2020 | |
| 2019-10-19 | SMU over Temple | 2019 | |
| 2019-08-31 | Ohio State over Florida Atlantic | 2019 | |
| 2018-11-24 | Georgia over Georgia Tech | 2018 | |
| 2018-09-29 | Troy over Coastal Carolina | 2018 | |
| 2017-11-26 | LSU over Texas A&M | 2017 | |
| 2017-09-16 | Texas A&M over Louisiana | 2017 | |
| 2016-12-30 | Air Force over South Alabama | 2016 | Playoff |
| 2016-09-03 | Iowa over Miami (OH) | 2016 | |
| 2015-10-31 | Florida State over Syracuse | 2015 | |
| 2015-10-17 | TCU over Iowa State | 2015 | |
| 2015-09-19 | Navy over East Carolina | 2015 | |
| 2015-09-19 | LSU over Auburn | 2015 | |
| 2014-12-31 | Stanford over Maryland | 2014 | Playoff |
| 2014-11-08 | Troy over Georgia State | 2014 | |
| 2014-08-30 | Auburn over Arkansas | 2014 | |
| 2014-08-30 | Georgia over Clemson | 2014 | |
| 2013-11-16 | Penn State over Purdue | 2013 | |
| 2013-09-21 | Georgia over North Texas | 2013 | |
| 2011-11-26 | Air Force over Colorado State | 2011 | |
| 2011-11-19 | Alabama over Georgia Southern | 2011 | |
| 2011-11-13 | Notre Dame over Maryland | 2011 | |
| 2011-10-08 | Western Michigan over Bowling Green | 2011 | |
| 2010-10-09 | Virginia Tech over Central Michigan | 2010 | |
| 2010-09-25 | UConn over Buffalo | 2010 | |
| 2008-11-08 | Texas over Baylor | 2008 | |
| 2008-08-30 | Georgia over Georgia Southern | 2008 | |
| 2007-10-13 | Air Force over Colorado State | 2007 | |
| 2006-11-02 | Boise State over Fresno State | 2006 | |
| 2005-10-22 | Boise State over Utah State | 2005 | |
| 2005-10-15 | Oregon over Washington | 2005 | |
| 2005-10-15 | UTEP over Tulane | 2005 | |
| 2005-09-17 | Iowa over Northern Iowa | 2005 | |
| 2004-10-23 | Kansas State over Nebraska | 2004 | |
| 2004-09-11 | Fresno State over Kansas State | 2004 | |
| 2003-08-30 | Marshall over Hofstra | 2003 | |
| 2002-11-16 | Iowa over Minnesota | 2002 | |
| 2002-11-09 | UCF over Buffalo | 2002 | |
| 2002-08-24 | Ohio State over Texas Tech | 2002 | |
| 2001-09-30 | Air Force over San Diego State | 2001 | |
| 2000-11-02 | Colorado State over BYU | 2000 | |
| 1999-11-20 | Toledo over Western Michigan | 1999 | |
| 1999-11-13 | Navy over Tulane | 1999 | |
| 1999-10-02 | Northern Illinois over Buffalo | 1999 | |
| 1999-09-04 | Tulsa over Missouri State | 1999 | |
| 1997-11-08 | USC over Stanford | 1997 | |
| 1997-11-08 | Miami (OH) over Ohio | 1997 | |
| 1997-10-18 | Miami (OH) over Marshall | 1997 | |
| 1997-10-11 | Notre Dame over Pittsburgh | 1997 | |
| 1997-10-04 | Missouri over Iowa State | 1997 | |
| 1996-10-26 | BYU over TCU | 1996 | |
| 1996-09-07 | East Carolina over East Tennessee State | 1996 | |
| 1995-10-28 | Penn State over Indiana | 1995 | |
| 1995-09-30 | UCLA over Fresno State | 1995 | |
| 1995-09-02 | New Mexico over Northern Arizona | 1995 | |
| 1995-09-02 | Florida over Houston | 1995 | |
| 1994-09-10 | BYU over Air Force | 1994 | |
| 1993-11-13 | Fresno State over Hawai'i | 1993 | |
| 1993-09-11 | Colorado over Baylor | 1993 | |
| 1992-09-05 | Ole Miss over Auburn | 1992 | |
| 1991-11-02 | Arizona over Oregon State | 1991 | |
| 1991-09-28 | Arizona over Long Beach State | 1991 | |
| 1991-01-01 | Georgia Tech over Nebraska | 1990 | Playoff |
| 1990-10-20 | Hawai'i over Cal State Fullerton | 1990 | |
| 1990-10-13 | Pittsburgh over Rutgers | 1990 | |
| 1989-09-16 | West Virginia over South Carolina | 1989 | |
| 1988-10-15 | Florida State over East Carolina | 1988 | |
| 1987-11-28 | Houston over Rice | 1987 | |
| 1985-11-16 | Eastern Kentucky over Louisville | 1985 | |
| 1984-10-13 | South Carolina over Pittsburgh | 1984 | |
| 1982-11-27 | Hawai'i over Air Force | 1982 | |
| 1981-10-03 | Wyoming over UNLV | 1981 | |
| 1981-09-12 | BYU over Air Force | 1981 | |
| 1980-10-04 | West Virginia over Virginia | 1980 | |
| 1980-09-27 | Lamar over Stephen F. Austin | 1980 | |
| 1977-11-19 | Ball State over Eastern Michigan | 1977 | |
| 1977-10-15 | Washington over Stanford | 1977 | |
| 1977-09-10 | SMU over TCU | 1977 | |
| 1976-11-13 | Oklahoma State over Kansas State | 1976 | |
| 1974-10-19 | BYU over UTEP | 1974 | |
| 1971-10-30 | Memphis over Cincinnati | 1971 | |
| 1970-11-28 | Utah State over New Mexico State | 1970 | |
| 1970-10-24 | Texas over Rice | 1970 | |
| 1968-11-09 | Oregon State over UCLA | 1968 | |
| 1968-10-19 | Ohio State over Northwestern | 1968 | |
| 1968-09-21 | Toledo over Villanova | 1968 | |
| 1968-09-21 | Notre Dame over Oklahoma | 1968 | |
| 1966-11-26 | Florida State over Maryland | 1966 | |
| 1949-11-19 | Villanova over NC State | 1949 |