Has a College Football game ever ended 46-6?
It has. 46-6 has been a College Football final 42 times in 84,433 games. The first was Tufts beat Dean Academy on October 28, 1893; the latest was Air Force beat Navy on October 12, 1991.
That makes 46-6 the 457th most common final score out of 2,216 that have ever occurred in College Football. One point away, 47-6 has happened 53 times and 46-7 has happened 48 times.