Has a College Football game ever ended 46-8?
It has. 46-8 has been a College Football final 3 times in 84,334 games. The first was Michigan beat Purdue on November 11, 1893; the latest was Delaware beat Lehigh on October 24, 1964.
That makes 46-8 the 1476th most common final score out of 2,215 that have ever occurred in College Football. One point away, 47-8 has happened 6 times and 46-9 has happened 3 times. At one point the score disappeared for 62 years, between 1893 and 1955.