Has a College Football game ever ended 5-1?
It has. 5-1 has been a College Football final 3 times in 84,433 games. The first was Yale beat Columbia on November 21, 1874; the latest was Stevens beat Michigan on November 27, 1883.
That makes 5-1 the 1476th most common final score out of 2,216 that have ever occurred in College Football. One point away, 6-1 has happened 3 times and 5-2 has happened 3 times. Nearly all of its occurrences fall between 1860 and 1889.