Has a College Football game ever ended 50-16?
It has. 50-16 has been a College Football final 3 times in 84,334 games. The first was Utah beat Wyoming on October 13, 1973; the latest was Tennessee beat Kentucky on November 15, 2014.
That makes 50-16 the 1476th most common final score out of 2,215 that have ever occurred in College Football. One point away, 51-16 has happened 4 times and 50-17 has happened 9 times. At one point the score disappeared for 37 years, between 1973 and 2010.