Has a College Football game ever ended 50-2?

Exactly once. On November 10, 1888, Harvard beat Wesleyan (CT) 50-2, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 50-2 in league history.

Where 50-2 sits among nearby College Football scores. Deeper blue means a score has happened more often; the outlined cell is the new one.

That makes 50-2 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 51-2 has happened 1 times and 50-3 has happened 7 times.

Every 50-2 in College Football history

Date	Result	Season
1888-11-10	Harvard over Wesleyan (CT)	1888

Open the College Football grid at 50-2