Has a College Football game ever ended 50-22?
Yes. College Football has seen a final score of 50-22 4 times. It first happened on November 20, 1976, when Florida beat Rice, and most recently on November 11, 2017, when Ole Miss beat Louisiana.
That makes 50-22 the 1361st most common final score out of 2,215 that have ever occurred in College Football. One point away, 51-22 has happened 4 times and 50-23 has happened 3 times.