Has a College Football game ever ended 50-33?
Yes. College Football has seen a final score of 50-33 3 times. It first happened on October 27, 2001, when Marshall beat Akron, and most recently on October 1, 2016, when Notre Dame beat Syracuse.
That makes 50-33 the 1476th most common final score out of 2,215 that have ever occurred in College Football. One point away, 51-33 has happened 3 times and 50-34 has happened 1 times.