Has a College Football game ever ended 51-43?
Yes. College Football has seen a final score of 51-43 4 times. It first happened on December 25, 1998, when Colorado beat Oregon, and most recently on September 30, 2017, when UL Monroe beat Coastal Carolina.
That makes 51-43 the 1362nd most common final score out of 2,216 that have ever occurred in College Football. One point away, 52-43 has happened 3 times and 51-44 has happened 3 times. Nearly all of its occurrences fall between 1980 and 2009.