Has a College Football game ever ended 52-48?
Exactly once. On January 1, 2014, Texas A&M beat Duke 52-48, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 52-48 in league history.
That makes 52-48 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 53-48 has happened 1 times and 52-49 has happened 9 times.