Has a College Football game ever ended 53-2?
It has. 53-2 has been a College Football final 3 times in 84,433 games. The first was Harvard beat Amherst on October 8, 1898; the latest was Kentucky beat Vanderbilt on November 11, 1978.
That makes 53-2 the 1476th most common final score out of 2,216 that have ever occurred in College Football. One point away, 54-2 has happened 4 times and 53-3 has happened 4 times. At one point the score disappeared for 42 years, between 1898 and 1940.