Has a College Football game ever ended 53-27?
Exactly once. On September 25, 1949, Nevada beat Portland 53-27, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 53-27 in league history.
That makes 53-27 the 1824th most common final score out of 2,217 that have ever occurred in College Football. One point away, 54-27 has happened 6 times and 53-28 has happened 6 times.
Every 53-27 in College Football history
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