Has a College Football game ever ended 53-32?
Exactly once. On October 31, 2010, Oregon beat USC 53-32, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 53-32 in league history.
That makes 53-32 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 54-32 has happened 4 times and 53-33 has happened 3 times.