Has a College Football game ever ended 53-45?
Yes. College Football has seen a final score of 53-45 2 times. It first happened on November 7, 2004, when Wyoming beat UNLV, and most recently on October 10, 2020, when Oklahoma beat Texas.
That makes 53-45 the 1611th most common final score out of 2,216 that have ever occurred in College Football. One point away, 54-45 has happened 1 times and 53-46 has happened 1 times.