Has a College Football game ever ended 53-48?
Exactly once. On December 19, 2020, LSU beat Ole Miss 53-48, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 53-48 in league history.
That makes 53-48 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 54-48 has happened 7 times and 53-49 has happened never.