Has a College Football game ever ended 54-4?
Exactly once. On October 21, 1907, Sewanee beat Alabama 54-4, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 54-4 in league history.
That makes 54-4 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 55-4 has happened never and 54-5 has happened never.