Has a College Football game ever ended 57-16?
Yes. College Football has seen a final score of 57-16 2 times. It first happened on November 29, 1969, when Oregon beat Hawai'i, and most recently on October 5, 2013, when Oregon beat Colorado.
That makes 57-16 the 1610th most common final score out of 2,215 that have ever occurred in College Football. One point away, 58-16 has happened 4 times and 57-17 has happened 3 times. At one point the score disappeared for 44 years, between 1969 and 2013.