Has a College Football game ever ended 57-42?
Exactly once. On October 12, 1991, Utah beat Wyoming 57-42, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 57-42 in league history.
That makes 57-42 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 58-42 has happened 5 times and 57-43 has happened never.