Has a College Football game ever ended 6-1?
Yes. College Football has seen a final score of 6-1 3 times. It first happened on October 18, 1873, when Stevens beat New York University, and most recently on December 5, 1874, when Yale beat Columbia.
That makes 6-1 the 1476th most common final score out of 2,216 that have ever occurred in College Football. One point away, 7-1 has happened never and 6-2 has happened 49 times. Nearly all of its occurrences fall between 1860 and 1889.