Has a College Football game ever ended 65-20?
Exactly once. On September 29, 1972, UCLA beat Oregon 65-20, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 65-20 in league history.
That makes 65-20 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 66-20 has happened 1 times and 65-21 has happened 4 times.