Has a College Football game ever ended 65-43?
Exactly once. On October 16, 2010, Auburn beat Arkansas 65-43, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 65-43 in league history.
That makes 65-43 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 66-43 has happened never and 65-44 has happened 1 times.