Has a College Football game ever ended 65-5?
Exactly once. On October 7, 1911, Arkansas beat Drury 65-5, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 65-5 in league history.
That makes 65-5 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 66-5 has happened never and 65-6 has happened 8 times.