Has a College Football game ever ended 65-51?
Exactly once. On November 23, 2007, Colorado beat Nebraska 65-51, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 65-51 in league history.
That makes 65-51 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 66-51 has happened 1 times and 65-52 has happened never.