Has a College Football game ever ended 65-8?
Exactly once. On September 19, 1981, BYU beat UTEP 65-8, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 65-8 in league history.
That makes 65-8 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 66-8 has happened 1 times and 65-9 has happened 2 times.