Has a College Football game ever ended 66-16?
Yes. College Football has seen a final score of 66-16 2 times. It first happened on October 6, 1973, when UCLA beat Utah, and most recently on September 15, 2012, when Tulsa beat Nicholls.
That makes 66-16 the 1611th most common final score out of 2,216 that have ever occurred in College Football. One point away, 67-16 has happened never and 66-17 has happened 9 times. At one point the score disappeared for 39 years, between 1973 and 2012.