Has a College Football game ever ended 68-10?
Exactly once. On October 28, 2006, Hawai'i beat Idaho 68-10, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 68-10 in league history.
That makes 68-10 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 69-10 has happened 4 times and 68-11 has happened never.