Has a College Football game ever ended 72-11?
Exactly once. On November 12, 1904, Williams beat Vermont 72-11, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 72-11 in league history.
That makes 72-11 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 73-11 has happened never and 72-12 has happened never.