Has a College Football game ever ended 72-15?
Exactly once. On October 1, 1977, Texas beat Rice 72-15, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 72-15 in league history.
That makes 72-15 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 73-15 has happened never and 72-16 has happened never.