Has a College Football game ever ended 72-42?
Exactly once. On October 19, 2012, SMU beat Houston 72-42, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 72-42 in league history.
That makes 72-42 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 73-42 has happened 1 times and 72-43 has happened 1 times.