Has a College Football game ever ended 72-45?
Exactly once. On December 8, 2001, Hawai'i beat BYU 72-45, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 72-45 in league history.
That makes 72-45 the 1819th most common final score out of 2,215 that have ever occurred in College Football. One point away, 73-45 has happened never and 72-46 has happened never.