Has a College Football game ever ended 74-20?
Exactly once. On January 2, 1950, Stanford beat Hawai'i 74-20, and no College Football game before or since has ended that way. When it happened it was a scorigami, the first 74-20 in league history.
That makes 74-20 the 1820th most common final score out of 2,216 that have ever occurred in College Football. One point away, 75-20 has happened never and 74-21 has happened never.